Family members

Some Mr. Men and Little Misses are related to each other, and also have mentioned unseen members too.

With each other

• Little Miss Twins — The book is mainly about two twin sisters.
• Little Miss Whoops — Mr. Bump is Miss Whoops's brother.
• Little Miss Chatterbox — Mr. Chatterbox is Miss Chatterbox's brother.
• Mr. Fussy — Mr. Fussy and Mr. Clumsy are cousins.
• "Hello, Pizza Express?" — Little Miss Chatterbox claims Mr. Busy is a distant cousin of Mr. Rush, who is related Mr. Fussy in and of himself.
• Little Miss Fabulous — Little Miss Splendid and Little Miss Fabulous are cousins.
• Mr. Greedy — Mr. Greedy is Little Miss Greedy's brother.

Offscreen/Minor characters

• Mr. Mean — Mr. Mean has a brother whom he only gives coal to.
• Little Miss Princess - Little Miss Princess has a mother and father who are the Queen and King of Misterland.
• Mr. Chatterbox loses his voice — Mr. Chatterbox had a father, a grandfather, and a great grandfather who all wore green hats.
• Little Miss Splendid's Gift — Miss Splendid has cousins in Seatown.
• Hello, Pizza Express? — Miss Chatterbox has an aunt, a cousin, an uncle, and an in-law who has red hair.
• "Paint" — Miss Chatterbox had an uncle who couldn't stand still while being painted due to having hiccups.
• Little Miss Tidy Tidies Her Kitchen - Little Miss Tidy reveals that she has a grandmother who made soup tureen.

Onscreen/Minor characters

• "Sneezes and Hiccups" — Mr. Rude's family appears at the Dillydale Glee Club concert.
• "Rainy Day" — a photo of a Mr. Fussy's mother appears in his house.

Gallery

Little Miss Whoops and Mr. Bump

Little Miss Chatterbox and Mr. Chatterbox

Little Miss Twins

Mr. Clumsy and Mr. Fussy

Little Miss Greedy and Mr. Greedy

Little Miss Fabulous and Little Miss Splendid

Mr. Rude's family

Mr. Fussy's mother